Mar
08
2011

DRUGS TO TREAT RHEUMATOID ARTHRITIS: ENBREL

DRUGS TO TREAT RHEUMATOID ARTHRITIS: ENBREL
Enbrel is the brand name for etanercept, a modern biological response modifier.
There is a cytokine, or chemical messenger, present in the joints called tumor necrosis factor (TNF). This inflammatory mediator is one of the major problem-causing cytokines in RA. (It gets its name because it was found to cause weight loss and the shrinkage of tumors in young animals. Many years ago, it was actually thought of as a means of controlling cancer.) On cells there is a docking mechanism called a cytokine receptor. In order for cytokine (a chemical messenger) to do its job, it must join with a receptor. Enbrel is a laboratory-made receptor. Instead of docking at the regular receptor, the TNF sticks to the laboratory-made receptor Enbrel and is inactivated.
Enbrel is taken by subcutaneous (under the skin) injection twice a week. Most patients administer the injection themselves. It is relatively easy once becoming accustomed to it.
There can be some local allergic reactions at the site of injection. You can also experience headaches, fever, low blood pressure, and upset stomach. If you develop an infection on the drug, you must call your doctor. You will probably have to stop the drug until the infection is treated and you are well enough to start it again.
Your doctor should write a special prescription for you, and you will have to learn how to inject the drug from the doctor.
The drug it can be used with almost anything, including methotrexate.
*37/141/5*
Enbrel is the brand name for etanercept, a modern biological response modifier.
There is a cytokine, or chemical messenger, present in the joints called tumor necrosis factor (TNF). This inflammatory mediator is one of the major problem-causing cytokines in RA. (It gets its name because it was found to cause weight loss and the shrinkage of tumors in young animals. Many years ago, it was actually thought of as a means of controlling cancer.) On cells there is a docking mechanism called a cytokine receptor. In order for cytokine (a chemical messenger) to do its job, it must join with a receptor. Enbrel is a laboratory-made receptor. Instead of docking at the regular receptor, the TNF sticks to the laboratory-made receptor Enbrel and is inactivated.
Enbrel is taken by subcutaneous (under the skin) injection twice a week. Most patients administer the injection themselves. It is relatively easy once becoming accustomed to it.
There can be some local allergic reactions at the site of injection. You can also experience headaches, fever, low blood pressure, and upset stomach. If you develop an infection on the drug, you must call your doctor. You will probably have to stop the drug until the infection is treated and you are well enough to start it again.
Your doctor should write a special prescription for you, and you will have to learn how to inject the drug from the doctor.
The drug it can be used with almost anything, including methotrexate.
*37/141/5*
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Written by admin in: Arthritis |

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